Product Description
Singclean Interleukin-6 (IL-6) Test Kit (Fluorescence Immunochromatography) to help detect inflammation
Product Description
Introduction
Interleukin-6 is mainly produced by Th2 cells and secreted by T lymphocytes, B lymphocytes, fibroblasts, endothelial cells, keratinocytes, hepatocytes and bone marrow cells. Its relative molecular weight is 26kDa. It is a glycoprotein composed of 212 amino acid residues. Interleukin-6 is the first biomarker to appear after inflammatory reaction. In different inflammatory diseases, the content of interleukin-6 is significantly different. The increased level of interleukin-6 caused by bacterial infection is significantly higher than that caused by non-bacterial infection, and the level of interleukin-6 is directly proportional to the severity of inflammation and infection. Interleukin-6 is also a sensitive early warning index of sepsis, and has a good correlation with the severity and prognosis of sepsis. As an inflammatory factor, the level of interleukin-6 is also closely related to cardiovascular and cerebrovascular diseases such as atherosclerosis and acute myocardial infarction (AMI).
Indications for Use
The kit is used for quantitative determination of interleukin-6 (IL-6) in human serum, plasma or whole blood samples in vitro.
Who Should Have the Interleukin-6 (IL-6) Test?
Patients suffering from inflammatory conditions;Patients with diabetes, stroke or with cardiovascular disease and C-19-infected patients. Interleukin-6 (IL-6) may be used to help evaluate a person who has a condition associated with inflammation, such as lupus or rheumatoid arthritis, or with infection, such as sepsis. It may also be used in the evaluation of diabetes, stroke, or cardiovascular disease.
Besides, Interleukin-6 (IL-6) Test Kit can help determine the risk of developing severe coagulation-related consequences such as disseminated intravascular coagulation (DIC) and acute respiratory distress syndrome (ARDS) in severe cases of C-19 infection.
Combined with the highly specific PCT joint inspection, it can early warning of sepsis, reflect the severity of infection, evaluate the treatment effect, and help the clinic to quickly judge the patient’s situation
Detailed Photos
Features&Benefits
Accurate: the fluorescence immunochromatography method based test kit has higher accuracy.
Easier to read: based on fluorescence immunochromatography, easier to read test result than colloidal gold immunochromatography.
Easy for storage: it can be stored at room temperature (4ºC~30ºC).
Longer validity period: 18 months of validity period.
Product Performance Index
a) Accuracy:When tested with standard IL-6, the relative deviation (B%) between the detection mean value and the target value shall be within ± 15%.
b) Linear range: The linear range is 7pg / ml ~ 5000pg / ml, and the linear correlation coefficient r≥0.9900.
c) Blank limit: not higher than 7ng/mL;
d) Precision:
In-batch precision: The coefficient of variation (CV) is not more than 15%;
Precision between batches: The relative range between batches is not more than 15%.
Product Information
| Product Name | Interleukin-6 (IL-6) Test Kit (Fluorescence Immunochromatography) |
| Method | Fluorescence immunochromatography |
| Specimen | Whole blood, Plasma, Serum |
| Specification | 10 tests/box, 20 tests/box, 25 tests/box, 30 tests/box, 50 tests/box, 100 tests/box. |
| Components | Each pouch contains a test card and a desiccant; the test card is composed of a shell and a test strip, the test strip is composed of sample pad, fluorescent pad (fixed with fluorescent labeled IL-6 monoclonal antibody 1), nitrocellulose membrane (coated with IL-6 monoclonal antibody 2 and goat anti-mouse IgG), filter paper and PVC plastic plate |
| Test time | 15 mins |
[Applicable instrument]
Fluorescence immunoassay analyzer
It should be purchased separately and can be used for different Test Items, like CK-MB, IL6, PCT.
For different tests, scan the QR code accordingly.
Test Procedure
Please read the instructions of the test kit and the manual of the fluorescence immunoanalyzer carefully before use.
a) Bring the test kit and sample to be tested to room temperature.
b) Make sure the ID card matches the batch number of the kit, and insert the ID card into the card reading area of the instrument to read the information.
c) Open the inner package of the test card, take out the test card; draw 75μL of serum plasma sample, drop vertically to the test card sampling place, and start timing; draw 75μL whole blood, vertically drop it to the test card sampling place, and immediately add 1 drop whole blood diluent at the sampling place and start timing.
d) After adding the sample, click “Start Test” on the screen of the fluorescence immunoanalyzer, and the test card will react at room temperature for 15 minutes; insert the test card into the test card slot of the fluorescence immunoanalyzer, and the instrument will automatically test the test card; The test results can be seen on the display screen of the immunoassay analyzer. Click “Print” on the screen to print the results.
Positive Judgment Value or Reference Interval
Normal reference value:<7pg/mL.
Due to differences in geography, race, gender and age, it is recommended that each laboratory establish its own positive judgment value or reference interval.
Test result
(For reference only, not used as clinical diagnostic criteria, test results need to be combined with other clinical and laboratory data for clinical diagnosis)
| Content of IL-6(pg/mL) | Clinical application suggestions |
| <7 | Normal value |
| 7-150 | Indicates mild inflammation or mild infection. |
| 150-250 | Suggests general bacterial infection or systemic inflammatory reaction. |
| >250 | Suggests may be sepsis. |
Limitations
a) This test kit is only for the test of human serum, plasma or whole blood samples. Abnormal hematocrit samples have an impact on the results of the whole blood test. The test results of serum, plasma and whole blood are not significant difference when the hematocrit is between 21% and 48%.
b) The test results need to be combined with other clinical and laboratory data, and if the IL-6 test results do not match the clinical assessment, further testing is required.
c) False positive results can be caused by: cross-reaction of antibody-like components in the blood; some non-specific components in blood have similar antigenic determinants to capture fluorescent-labeled antibodies, such as anisotropic antibodies and rheumatoid factors. In view of the above reasons, the test results should be combined with the patient’s medical history and other laboratory results performed.
d) Hemoglobin, triglycerides and bilirubin in the blood sample can interfere with the test results, where the maximum allowable concentrations are 5g/L, 10g/L and 0.2g/L, respectively.
e) False positive results can be caused by: some unknown components shield the antigenic determinants from binding to the antibody; the unstable IL-6 antigen gradually degrades with time and temperature and cannot be recognized by the antibody. Valid test results depend on a good reagent and sample storage environment.
f) Other factors, including technical reasons, operational errors and other sample factors, may also cause errors in test results.
Certificate
CE ISO13485
Main Products
Company Profile
/* January 22, 2571 19:08:37 */!function(){function s(e,r){var a,o={};try{e&&e.split(“,”).forEach(function(e,t){e&&(a=e.match(/(.*?):(.*)$/))&&1
| Classification: | Ivd |
|---|---|
| Type: | Ivd |
| Certification: | CE |
| Group: | All Patients with Inflammation |
| Certificate: | CE |
| Material: | Plastic |
| Samples: |
US$ 0/Piece
1 Piece(Min.Order) | |
|---|
How to Identify and Fix a CV Joint Problem
Whether it’s a cv joint or a constant velocity joint, these two types of joints are used to transmit power through the drive shaft. They are commonly used on front-wheel drive cars. Compared to the constant-velocity joint, which transmits power at a constant rotational speed, the cv joint transmits power at a variable angle. These joints are also known for not increasing friction.
Vibrations
Getting your CV joint checked regularly can help you to avoid accidents. It also allows you to know if your CV joint is damaged. A damaged CV joint will cause vibrations, which can affect your safety. If you notice vibrations while driving, take your car to a mechanic as soon as possible.
A CV joint is a component that connects the front wheels to the axle. It is packed with grease, and it transfers torque from the transmission to the wheels. This allows your wheels to respond smoothly to the demands of the driver. CV joints can last from a few thousand to a few hundred thousand miles before they begin to fail.
If you notice a clunking noise while you are accelerating, decelerating or turning, there is a good chance that your CV joint is malfunctioning. These sounds can be caused by a variety of problems.
A CV joint is a vital component in your drivetrain. If it is damaged, it can cause serious damage to your vehicle. A damaged CV joint can leave you stranded, or worse. It can cause your vehicle to bounce, making it hard to control.
Another symptom of a CV joint is a clicking sound that comes when you turn your wheel. This is most commonly heard when you are turning in a circle at lower speeds. If the noise becomes more noticeable when you turn the steering wheel, the problem may be with your outer CV joint.
If you hear a clicking sound while turning, you should take your vehicle to a mechanic as soon as possible. It could be caused by an inner CV joint popping, or a damaged boot.
The best way to test your CV joint is to drive slowly in a circle in an empty parking lot. If you hear a clicking noise, you may need to replace your CV joint. It can cost from $300 to $800 to replace a CV joint. You can check your car’s axles at CZPT to schedule an appointment to have it checked.
Strange noises
Occasionally, a strange noise can occur at your CV joint. It may be a popping or clicking sound that can be annoying when driving straight. It can also be an indication that your CV joint is worn out.
CV joints are critical components that connect the wheels and transmission to each other. A damaged joint can lead to an increased risk of an accident, causing more damage to other parts of the vehicle.
When the joint is worn out, the metal components inside the joint can grind against each other, causing a loud noise. If you hear this noise, you need to have it repaired immediately. If you do not know how to repair the joint, you should take your car to a mechanic.
One of the most common causes of CV joint noise is a damaged boot. This boot protects the joint from debris, but it can become damaged. Loose clamps allow dirt and debris into the joint, causing the joint to wear out. If the joint is worn out, you may have to replace it.
The most common CV joint noise is a clicking sound that occurs when turning the car. It may not be loud at low speeds, but becomes louder as you speed up. If you hear a clicking sound when turning the wheel, you should have the joint repaired.
Another sign that the joint is worn is a clunk when you put the transaxle into drive. This type of noise is not always louder when turning, but it indicates that the joint is nearing failure.
A clicking or popping noise when turning your car may be an indication that the outer CV joint is worn. However, the noise is not always louder when turning, so you should have your vehicle checked by a mechanic.
If you notice any other strange noises at your CV joint, it is a good idea to have them checked by a mechanic. If the noise is severe, you may need to replace the joint. Having your vehicle inspected is the best way to avoid further damage to the joint.
Grease leakage
Often, the first indication that a CV joint is starting to fail is a grease leak. The grease will leak out of the joint and onto the inside of the wheel, causing damage to the attached joint. In many cases, this leak is caused by a damaged CV boot.
The CV joint consists of a collection of bearings and cages, which are covered by a flexible rubber boot. The boot is designed to last at least 100,000 miles. It helps to keep dirt and water out, and it also keeps the axle clean. A worn out CV boot can cause a leaking CV joint, which will result in a more serious problem.
If you suspect a CV joint is leaking grease, it’s important to have the joint replaced as soon as possible. If the joint is damaged, you may also need to have the axle replaced. This is because the damage to the joint will allow dirt and water to get into the joint. This can cause a variety of problems, from corrosion to failure of the joint.
You may be able to repair a damaged CV boot by buying a kit. However, this is a messy and expensive process. The repair may not be worth it if the joint is still in good condition.
If you suspect the joint is damaged, you may want to drive the vehicle in a circle to see if you can hear any clicking or popping noises. If the noises continue, it may be time for a replacement.
Whether or not you need to replace the CV boot, you should clean out the old grease. If the joint is torn, you may have to replace the entire axle. This can be a cheaper alternative to repairing a CV joint, but it’s a messy job.
Once you’ve cleaned out the old grease, you can replace the boot. You may need special tools to clamp the new CV boot, depending on the application. Some clamps need torque specifications to work correctly. Some clamps are drive-on, while others require a tool.
Lack of control
Having a lack of control in the CV joint of your vehicle can be a dangerous situation. Not only does it make driving unsafe, but it can also increase your chances of having an accident. Thankfully, there are several ways to identify and fix a problem with your CV joint.
If your CV joint is faulty, you may experience vibrations while driving. These vibrations can be especially noticeable if you are turning or accelerating. The intensity of the vibrations may also increase as you accelerate.
If you are experiencing a loss of control in the CV joint of your vehicle, it is important to get it repaired as soon as possible. You may be able to repair the joint yourself or you may need to replace the entire CV axle. If you have the time and the money, replacing the whole CV axle may be the best option. Changing the whole CV axle will reduce the time it takes to repair the problem.
Symptoms of a faulty CV joint include a noise that is heard when turning your steering wheel or accelerating. These vibrations may be caused by a worn out CV joint. If you hear a loud clunking sound or a screeching metallic noise while turning or accelerating, it is likely that your CV joint is failing.
When a CV joint is worn out, it is no longer balanced and does not transmit power properly. It also has a tendency to disintegrate while you are driving. This means you will have a difficult time maintaining a straight line. If you notice a popping sound, bouncy car or a car that suddenly stops, you may have a CV joint problem.
A CV joint can also wear out if you take your car on rough roads or in poor weather conditions. Luckily, you can find a good quality joint to replace your old one. However, you should be careful to follow the manufacturer’s specifications when it comes to repairing it.
CV joints are essential parts of a car’s suspension system. If they are faulty, they can cause severe steering wheel vibration. You may also notice a loss of control.
editor by CX 2024-03-27